据《中华医学杂志英文版》最新在线发表的论文报道，中国科学家发现 miR542 靶向 AEG-1 基因明显抑制胶质母细胞瘤细胞上皮间充质转化。

脑胶质瘤 是最常见的中枢神经系统原发恶性肿瘤，其中胶质母细胞瘤（glioblastoma，GBM）发病率最高，其恶性程度高，预后不良。

上皮间充质转化（epithelial to mesenchymal transition，EMT）与肿瘤恶性程度相关，在肿瘤发生发展过程中发挥重要作用。

近来研究报道 microRNA 通过调控靶基因功能影响肿瘤 EMT 过程，已被认为在治疗恶性肿瘤中前景广泛。

中国人民解放军总医院第一医学中心神经外科医学部冯世宇/李翀团队以人脑胶质瘤中 astrocyte elevated gene（星形胶质细胞上调基因-1，AEG-1）为靶点，筛选出调控其功能的特异性 microRNA，并进一步探讨 miR542 通过调控 AEG-1 基因影响 GBM 增殖及侵袭的作用机理，为治疗脑胶质瘤提供重要参考。

据悉，该团队长期从事多模态术中磁共振及神经导航技术辅助下脑胶质瘤及深部肿瘤的手术治疗，并联合放射治疗科、病理科及神经肿瘤科等专家组成 MDT 团队制定并实施脑胶质瘤及转移瘤的放化疗及靶向等综合治疗，同时开展多项恶性神经肿瘤的基础与临床研究，均处于世界先进水平，为服务广大患者及推动科学进展做出了卓越贡献。

摘要如下

Researchers at the Department of Neurosurgery, the first Medical Center of Chinese PLA General Hospital have found that miR542 could suppress EMT of glioblastoma (GBM ) through targeting AEG-1.

GBM accounts for about half population of glioma, which is the multigene-related disorder. Despite significant progress in conventional strategies for tumor treatment, including surgery, chemotherapy and radiation, more effective but less toxic chemotherapeutic treatments for GBM are still urgently needed. Accumulated researches have reported that epithelial to mesenchymal transition (EMT ) plays a critical role in tumor invasion and progression. Furthermore, microRNAs affect significantly on EMT process by regulating the targeted genes.

In the current study, we investigated the effects of AEG-1 on U251 cell aggressiveness, proliferation and apoptosis. Then we focused on the miR542 as the regulator of AEG-1 gene via screening of targeted microRNAs. Our findings demonstrated that miR542 inhibited the migration and proliferation of U251 cells and further suppressed EMT process through targeting AEG-1. The results provide a new insight into GBM cell malignant phenotypes and a potential therapeutic target in the treatment of this tumor.